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KMID : 0387720050160010056
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Korean Journal of Blood Transfusion
2005 Volume.16 No. 1 p.56 ~ p.62
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The First Case of Posttransfusion Purpura Caused by anti-HPA-3a Antibody in Korea
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Song Sang-Hoon
Kim Dong-Chan
Kim Yang-Hyun
Jin Sang-Man
Yoon Sung-Soo
Seo Dong-Hee
Park Myoung-Hee
Han Kyou-Sup
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Abstract
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Posttransfusion purpura is a rare but potentially fatal disorder, characterized by the development of severe thrombocytopenia following transfusion. We report the first case of posttransfusion purpura in Korea in a 39-year-old multiparous woman. Nine days after transfusion of two units of red blood cells during cesarian section operation, she developed sudden onset of purpura, gum bleeding, and severe thrombocytopenia. Serological analysis revealed that the patient had antibodies against HPA-3a (Baka) and HLA. She was treated with plasmapheresis and the platelet count dramatically normalized. Though posttransfusion purpura is a self-limited disorder, early diagnosis and proper treatment can shorten the duration of the clinical course.
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